{"id":259,"date":"2024-11-01T09:40:32","date_gmt":"2024-11-01T08:40:32","guid":{"rendered":"http:\/\/wwww.icp.universite-paris-saclay.fr\/capri\/?page_id=259"},"modified":"2024-12-05T12:13:57","modified_gmt":"2024-12-05T11:13:57","slug":"bio-analysis","status":"publish","type":"page","link":"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/en\/bio-analysis\/","title":{"rendered":"Bio-analysis"},"content":{"rendered":"<div id=\"pl-259\"  class=\"panel-layout\" ><div id=\"pg-259-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-259-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-259-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h3 class=\"widget-title\">Bio-analysis<\/h3>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<\/div>\n<\/div><\/div><div id=\"panel-259-0-0-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"1\" ><div class=\"panel-widget-style panel-widget-style-for-259-0-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Ninette Abou Mrad (Associate Prof), Isabelle Billault (Associate Prof-HDR), Myriam Bonose (Associate Prof-HDR), Marine de Person (Associate Prof), Fr\u00e9d\u00e9ric Halgand (Senior Researcher-HDR), Sylvie H\u00e9ron (Associate Prof-HDR), Marie-Claude Menet (Prof), Antoine Pallandre (Prof), Guillaume van der Rest (Prof), Philippe Maitre (Senior Researcher), Fathi Moussa (Prof Emeritus), Ines-Isabel de Figeiredo (PhD Student), Terkia Bettioui (PhD Student), Eva Audouin (PhD Student)<br \/>\nAlumni: Ayoub Boulghobra (PhD 19-23), Lucas Lecorgne (PhD 20-23), Jan Bohl (PhD 16-19), Hala Dadi (PhD 15-18), Chiraz El Saddik (PhD 18-22), Yali Wang (PhD 18-22), Francis Berthias (PostDoc 17-19), Viet Nguyen (PostDoc 19-21), Eskander Alhajji (Long-term Visitor 18-22).<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-259-0-0-2\" class=\"so-panel widget widget_sow-editor\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>The Bio-analysis axis, led by Fr\u00e9d\u00e9ric Halgand, aims to utilize the diversity of available instruments to perform quantitative analyses of biomolecules related to medical issues. These efforts are carried out in collaboration with various stakeholders in the medical field.<\/p>\n<p>The instruments are grouped into two facilities:<\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><a href=\"https:\/\/www.icp.universite-paris-saclay.fr\/en\/smas-2\/\" target=\"_blank\" rel=\"noopener\">SMAS<\/a>, which includes the Synapt G2 (with TWIMS) and the laser-coupled instruments CLIO (FTICR 7T, RF trap).<\/li>\n<li><a href=\"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/en\/equipment\/letiam\/\">LETIAM<\/a>, which features two Triple Quad systems (Shimadzu, Thermo), an LTQ Orbitrap Velos, all coupled with chromatographic methods, and a GC 2D-ISQ.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>A flagship activity focuses on studying the lipidome of red blood cells, pursued in the search for biomarkers for Gaucher's disease. In collaboration with APHP (Beaujon Hospital), rapid and sensitive methods have allowed for the quantification of 30 lipid biomarkers in blood plasma (Thesis of Iheb Belarbi).<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-259-0-0-3\" class=\"so-panel widget widget_sow-image\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-image so-widget-sow-image-default-c67d20f9f743-259\"\n\t\t\t\n\t\t>\n<div class=\"sow-image-container\">\n\t\t<img \n\tsrc=\"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-content\/uploads\/sites\/2\/2024\/11\/C-4.jpg\" width=\"1381\" height=\"766\" srcset=\"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-content\/uploads\/sites\/2\/2024\/11\/C-4.jpg 1381w, https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-content\/uploads\/sites\/2\/2024\/11\/C-4-300x166.jpg 300w, https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-content\/uploads\/sites\/2\/2024\/11\/C-4-1024x568.jpg 1024w, https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-content\/uploads\/sites\/2\/2024\/11\/C-4-768x426.jpg 768w\" sizes=\"(max-width: 1381px) 100vw, 1381px\" title=\"C 4\" alt=\"\" \t\tclass=\"so-widget-image\"\/>\n\t<\/div>\n\n<\/div><\/div><div id=\"panel-259-0-0-4\" class=\"so-panel widget widget_sow-editor\" data-index=\"4\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: center;\"><em>Development of a new online SPE-HPLC-MS\/MS method for profiling and quantifying sphingolipids and phospholipids in red blood cells \u2013 Application to the study of Gaucher's disease. <\/em><em>[<\/em><em><a href=\"https:\/\/universite-paris-saclay.hal.science\/ICPO\/hal-04269346v1\">Bettioui2023<\/a>]<\/em><\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-259-0-0-5\" class=\"so-panel widget widget_sow-editor\" data-index=\"5\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>The conformational study of pathogenic proteins, notably prions and \u03b1-synuclein, relies on the combination of ion mobility and mass spectrometry. In collaboration with Human Rezaie (VIM Jouy-en-Josas), the team identified the smallest infectious structure of prions before expanding its research to \u03b1-synuclein (Thesis of Ines-Isabel de Figueiredo (2021-24)).<\/p>\n<p>Quantification of biomarkers in cerebrospinal fluid for early diagnosis of diseases, particularly the metabolomics of dopamine and biopterin, constituted the subject of Ayoub Boulghobra's thesis.<\/p>\n<p>Other collaborative projects include:<\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Analysis of the peptidome in joint fluid to identify biomarkers for osteoarthritis by examining hydrolysis phenomena and post-translational modifications of collagen in partnership with H\u00f4pital Cochin.<\/li>\n<li>Development of a rapid diagnostic for organic acidemias through DMS filtering coupled with mass spectrometry, in collaboration with H\u00f4pital Necker (Thesis of Chiraz El Saddik (2018-22)).<\/li>\n<li>Study of oxidative stress and the effects of irradiation on living organisms in collaboration with C\u00e9cile Sicard in the CPSysBio group.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><div id=\"panel-259-0-0-6\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"6\" ><div class=\"panel-widget-style panel-widget-style-for-259-0-0-6\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h3 class=\"widget-title\">Collaborations<\/h3>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>C\u00e9cile Sicard (CPSysBio, ICP), Didier Borderie (H\u00f4pital Cochin, Paris), Jean-Fran\u00e7ois Benoist (H\u00f4pital Necker, Paris), Human Rezaie (VIM, Jouy-en-Josas), Nadia Belmatoug (H\u00f4pital Beaujon, Paris)<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Ninette Abou Mrad (Associate Prof), Isabelle Billault (Associate Prof-HDR), Myriam Bonose (Associate Prof-HDR), Marine de Person (Associate Prof), Fr\u00e9d\u00e9ric Halgand (Senior Researcher-HDR), Sylvie H\u00e9ron (Associate Prof-HDR), Marie-Claude Menet (Prof), Antoine Pallandre (Prof), Guillaume van der Rest (Prof), Philippe Maitre (Senior Researcher), Fathi Moussa (Prof Emeritus), Ines-Isabel de Figeiredo (PhD Student), Terkia Bettioui (PhD Student), Eva&hellip;&nbsp;<a href=\"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/en\/bio-analysis\/\" rel=\"bookmark\">Lire la suite &raquo;<span class=\"screen-reader-text\">Bio-analysis<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"class_list":["post-259","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-json\/wp\/v2\/pages\/259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-json\/wp\/v2\/comments?post=259"}],"version-history":[{"count":5,"href":"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-json\/wp\/v2\/pages\/259\/revisions"}],"predecessor-version":[{"id":352,"href":"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-json\/wp\/v2\/pages\/259\/revisions\/352"}],"wp:attachment":[{"href":"https:\/\/www.icp.universite-paris-saclay.fr\/capri\/wp-json\/wp\/v2\/media?parent=259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}