As part of a long-term French-Belgian CNRS bilateral collaboration (IEA and IRP, 2016–2026) based on advanced optical spectral and electronic analysis (2C-SFG spectroscopy, UV-Vis absorption, time-resolved fluorescence), we are focused on the development, characterization, and application (sensors for medical diagnostics) of quantum dots (QDs) as cost-effective nanostructured platforms (CdTe QDs, 2 to 4 nm in diameter). This development relies on precise chemical grafting control of QDs on both transducer and non-transducer substrates (silicon, silica). Dipolar coupling (energy transfer) has been demonstrated for the first time between the first excitonic level of the QD and its chemical ligands using 2C-SFG spectroscopy [Noblet2018, Noblet2020] at the "Héméra" technical platform, supported by an original modeling approach based on loop Feynman diagrams applied to hybrid interfaces. This work bridges methodologies between optics and condensed matter physics [Noblet2021, Noblet2022]. These efforts led to Thomas Noblet receiving the 2020 Chancellerie des Universités de Paris Thesis Award in "all fields of science." Simultaneously, related research on gold nanomaterials at increasingly complex interfaces confirmed the observation of vibrational enhancement in SFG [Dalstein2018, Dalstein2019] and Raman (SERS) [Barbillon2020, Barbillon2022] responses of molecules grafted on AuNPs via surface plasmon coupling, all supported by extensive plasmonic modeling [Busson2019].