Study and Characterization of Post-Translational and Oxidative Modifications in Peptides

IRMPD spectroscopy is a vital tool for analyzing post-translational modifications. This is crucial because repair enzymes are only available for specific cases, such as the oxidation of a methionine residue to sulfoxide.

The diluted environment of the gas phase allows these modified species to be isolated, which are then structurally characterized using IR spectroscopy. [Maitre2020, Jiang2023]