The CPSysBio Group was established about twenty years ago with the objective of bringing together teams sharing a common interest in applying physical chemistry concepts to the study of biological mechanisms. Today, the group combines expertise in chemistry, physics, biochemistry, and cell biology. The members are organized into teams focused on a shared scientific interest around a broad concept (ionizing radiation, oxidative stress, etc.), a set of biological objects (flavoproteins, hemoproteins, fluorescent proteins, phagocytes), chemical objects (nanoparticles, ROS probes, etc.), or a specific methodology (AFM-IR nanospectroscopy, fluorescence lifetime imaging, etc.).

The group's research activities are structured into five thematic areas to which members contribute depending on the scientific projects. Two of these areas relate to redox biology, with the study of the NADPH oxidase complex (from signaling to molecular mechanisms) and the exploration of the various cause-and-effect links between oxidative stress and biological systems. One area focuses on the physicochemistry of nanoparticles and materials. Finally, two areas are dedicated to imaging strategies: one focuses on approaches using fluorescent proteins and biosensors, and the other on AFM-IR nanospectroscopy.